Role of Patatin-Like Phospholipase Domain-Containing 3 Gene for Hepatic Lipid Content and Insulin Resistance in Diabetes.
Oana P ZahariaKlaus StrassburgerBirgit KnebelYuliya KupriyanovaYanislava KarushevaMartin WolkersdorferKálmán BódisDaniel F MarkgrafVolker BurkartJong-Hee HwangJörg KotzkaHadi Al-HasaniJulia SzendroediMichael Rodennull nullPublished in: Diabetes care (2020)
Members of the SIRD cluster are more frequently carriers of the rs738409(G) variant. The SNP-associated adipose tissue insulin resistance and excessive lipolysis may contribute to their NAFLD.
Keyphrases
- adipose tissue
- insulin resistance
- genome wide
- glycemic control
- high fat diet
- type diabetes
- cardiovascular disease
- copy number
- polycystic ovary syndrome
- dna methylation
- weight gain
- high fat diet induced
- fatty acid
- high density
- genome wide identification
- metabolic syndrome
- gene expression
- skeletal muscle
- genetic diversity
- body mass index