The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells.

Te-Chuan ChenChia-Kung YenYing-Chen LuChung-Sheng ShiRong-Ze HsiehShun-Fu ChangCheng-Nan Chen

Published in: Cell & bioscience (2020)

This study elucidates the detailed mechanism of HG-initiated HASMC calcification through NLRP3/caspase 1/IL-1β inflammasome and indicates a potential therapeutic role of 6-shogaol in vascular calcification complication of diabetes.

Keyphrases

nlrp inflammasome
endothelial cells
high glucose
chronic kidney disease
type diabetes
cardiovascular disease
cell death
glycemic control
induced pluripotent stem cells
metabolic syndrome
pluripotent stem cells
insulin resistance
fluorescent probe
living cells