Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease.
Susanne Kristine AuneJoanna CwikielArnljot FlaaHarald ArnesenSvein SolheimAyodeji AwoyemiMarius TrøseidIngebjørg SeljeflotRagnhild HelsethPublished in: Cells (2021)
Elevated levels of gut leakage markers have been shown after strenuous exercise in healthy individuals. Any association between a temporary increase in these markers and the presence of coronary artery disease (CAD) is unknown. We therefore aimed to explore circulating gut leakage markers in response to a bout of strenuous exercise in patients with symptoms of CAD. Patients referred to exercise stress testing due to symptoms of CAD were included (n = 287). A maximal exercise ECG stress test was performed and venous blood samples were drawn at rest and within five minutes after, for analysis of soluble cluster of differentiation 14 (sCD14), lipopolysaccharide-binding protein (LBP), intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide (LPS) and gene expression of toll-like receptor 4 (TLR4) in circulating leukocytes. Patients then underwent coronary angiography. LPS, LBP and sCD14 increased significantly after strenuous exercise in patients with symptoms of CAD, suggesting that even short bouts of vigorous exercise are associated with gut leakage. The gene expression of TLR4 decreased significantly after exercise, possibly as a negative feedback to the increase in LPS. There were no differences in exercise-induced changes between the groups of CAD, suggesting gut leakage to be independent of the presence of CAD.
Keyphrases
- coronary artery disease
- toll like receptor
- high intensity
- inflammatory response
- physical activity
- gene expression
- resistance training
- binding protein
- end stage renal disease
- percutaneous coronary intervention
- cardiovascular events
- immune response
- chronic kidney disease
- newly diagnosed
- nuclear factor
- ejection fraction
- dna methylation
- coronary artery bypass grafting
- fatty acid
- body composition
- heart failure
- prognostic factors
- type diabetes
- heart rate
- atrial fibrillation
- acute coronary syndrome
- left ventricular
- aortic stenosis