Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).

Yao YeLin PengAurelia VattaiEileen DeusterChristina KuhnChristian DanneckerSven MahnerUdo JeschkeViktoria von SchönfeldtHelene H Heidegger

Published in: Journal of cancer research and clinical oncology (2020)

These results indicated that EP3 signaling pathway might facilitate the migration of cervical cancer cells through modulating uPAR expression. Therefore, EP3 and uPAR could represent novel therapeutic targets in the treatment of cervical cancer in advantaged stages.

Keyphrases

signaling pathway
poor prognosis
binding protein
induced apoptosis
oxidative stress
combination therapy
cell proliferation
replacement therapy