The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: A mechanistic review.
Tahere PasebanMohaddeseh Sadat AlaviLeila EtemadAli RoohbakhshPublished in: Expert opinion on therapeutic targets (2023)
ABCA1 via modulating normal and aberrant brain functions such as apoptosis, phagocytosis, BBB leakage, neuroinflammation, amyloid β efflux, myelination, synaptogenesis, neurite outgrowth, and neurotransmission promotes beneficial effects in aforementioned diseases. ABCA1 is a key molecule in the CNS. By boosting its expression or function, some CNS disorders may be resolved. In preclinical studies, liver X receptor agonists have shown promise in treating CNS disorders via ABCA1 and apoE enhancement.
Keyphrases
- blood brain barrier
- cerebral ischemia
- poor prognosis
- oxidative stress
- cell death
- endoplasmic reticulum stress
- high fat diet
- type diabetes
- white matter
- signaling pathway
- big data
- lps induced
- multiple sclerosis
- binding protein
- mesenchymal stem cells
- cell therapy
- metabolic syndrome
- adipose tissue
- inflammatory response
- cognitive impairment
- artificial intelligence
- deep learning
- pi k akt