Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.
Michael A DuranteStefan KurtenbachZoukaa B SargiJ William HarbourRhea ChoiSarah KurtenbachGarrett M GossHiroaki MatsunamiBradley J GoldsteinPublished in: Nature neuroscience (2020)
The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.
Keyphrases
- single cell
- rna seq
- stem cells
- endothelial cells
- high throughput
- poor prognosis
- spinal cord injury
- induced apoptosis
- spinal cord
- working memory
- electronic health record
- machine learning
- internal carotid artery
- long non coding rna
- big data
- cell death
- oxidative stress
- blood brain barrier
- cell therapy
- cell proliferation
- data analysis
- neural stem cells