Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis.
Danyal ImaniBahman RaziMorteza MotallebnezhadRamazan RezaeiPublished in: BMC neurology (2019)
This meta-analysis suggested a significant association between TaqI polymorphism and MS susceptibility. Furthermore, BsmI polymorphism was associated with increased risk of MS in Asian populations. In contrast, ApaI polymorphism was associated with decreased risk of MS in Asian populations. Future large-scale studies on gene-environment and gene-gene interactions are required to estimate risk factors and assist early diagnosis of patients at high risk for MS.
Keyphrases
- multiple sclerosis
- mass spectrometry
- systematic review
- ms ms
- risk factors
- end stage renal disease
- copy number
- genome wide
- case control
- white matter
- chronic kidney disease
- randomized controlled trial
- ejection fraction
- magnetic resonance
- newly diagnosed
- meta analyses
- genome wide identification
- magnetic resonance imaging
- peritoneal dialysis
- prognostic factors
- contrast enhanced