Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx).
Pouline Mp van OortTamara M NijsenIain R WhiteHugo H KnobelTimothy FeltonNicholas RattrayOluwasola LawalMurtaza BulutWaqar AhmedAntonio ArtigasPedro R PovoaIgnacio Martin-LoechesHans WedaRoyston GoodacreMarcus J SchultzPaul M DarkStephen J FowlerLieuwe D J Bosnull nullPublished in: Thorax (2021)
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.
Keyphrases
- end stage renal disease
- respiratory tract
- ejection fraction
- newly diagnosed
- chronic kidney disease
- gas chromatography mass spectrometry
- prognostic factors
- peritoneal dialysis
- pulmonary embolism
- clinical trial
- randomized controlled trial
- mass spectrometry
- bone marrow
- study protocol
- patient reported
- high resolution mass spectrometry