Intraoperative MRI-Guided Resection Is Not Superior to 5-Aminolevulinic Acid Guidance in Newly Diagnosed Glioblastoma: A Prospective Controlled Multicenter Clinical Trial.
Constantin RoderWalter StummerJan CoburgerMoritz SchererPatrick HaasChristian von der BrelieMarcel Alexander KampMario LöhrChristina A HamischMarco SkardellyTorben ScholzStephanie SchipmannJulian RathertCatrin Marlene BrandAndrej PalaUlrike ErnemannFlorian StockhammerRüdiger GerlachPaul KremerRoland GoldbrunnerRalf-Ingo ErnestusMichael SabelVeit RohdeGhazaleh TabatabaiPeter MartusSotirios BisdasOliver GanslandtAndreas UnterbergChristian Rainer WirtzMarcos TatagibaPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
We could not confirm superiority of iMRI over 5-ALA for achieving complete resections. Neurosurgical interventions in newly diagnosed glioblastoma shall aim for safe complete resections with 0 cm³ contrast-enhancing residual disease, as any other residual tumor volume is a negative predictor for PFS and OS.