Quantifying and addressing the prevalence and bias of study designs in the environmental and social sciences.
Alec Philip ChristieDavid AbecasisMehdi AdjeroudJuan Carlos AlonsoTatsuya AmanoÁlvaro AntónBarry P BaldigoRafael BarrientosJake E BicknellDeborah A BuhlJust CebrianRicardo S CeiaLuciana Cibils-MartinaSarah ClarkeJoachim ClaudetMichael D CraigDominique DavoultAnnelies De BackerMary K DonovanTyler D EddyFilipe M FrançaJonathan P A GardnerBradley P HarrisAri HuuskoIan L JonesBrendan P KelaherJanne S KotiahoAdria Lopez-BaucellsHeather L MajorAki Mäki-PetäysBeatriz MartínCarlos A MartínPhilip A MartinDaniel Mateos-MolinaRobert A McConnaugheyMichele MeroniChristoph F J MeyerKade MillsMonica MontefalconeNorbertas NoreikaCarlos PalacínAnjali PandeC Roland PitcherCarlos PonceMatt RinellaRicardo RochaMaría C Ruiz-DelgadoJuan Jacobo Schmitter-SotoJill A ShafferShailesh SharmaAnna A SherDoriane StagnolThomas R StanleyKevin D E StokesburyAurora TorresOliver TullyTeppo VehanenCorinne WattsQingyuan ZhaoWilliam J SutherlandPublished in: Nature communications (2020)
Building trust in science and evidence-based decision-making depends heavily on the credibility of studies and their findings. Researchers employ many different study designs that vary in their risk of bias to evaluate the true effect of interventions or impacts. Here, we empirically quantify, on a large scale, the prevalence of different study designs and the magnitude of bias in their estimates. Randomised designs and controlled observational designs with pre-intervention sampling were used by just 23% of intervention studies in biodiversity conservation, and 36% of intervention studies in social science. We demonstrate, through pairwise within-study comparisons across 49 environmental datasets, that these types of designs usually give less biased estimates than simpler observational designs. We propose a model-based approach to combine study estimates that may suffer from different levels of study design bias, discuss the implications for evidence synthesis, and how to facilitate the use of more credible study designs.