Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka.

Thanuri EdirithilakeNishantha NanayakkaraXiao Xiao LinPatrick J BiggsRohana ChandrajithSampath LokugalappattiSaumya Wickramasinghe

Published in: MicroRNA (Shariqah, United Arab Emirates) (2023)

Significant downregulation of miRNA and piRNA expression in both diseased and healthy endemic samples indicates an epigenetic regulation of CKDu involving genetic and environmental interaction. Further studies of specific miRNA species are required to develop a miRNA panel to identify individuals susceptible to CKDu.

Keyphrases

chronic kidney disease
poor prognosis
end stage renal disease
cell proliferation
signaling pathway
binding protein
gene expression
copy number
human health
data analysis