Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells.

Liza U Ljungberg Mulugeta Melkie Zegeye Caroline Kardeby Knut Fälker Dirk RepsilberAllan Sirsjö

Published in: Mediators of inflammation (2020)

In this study, a large number of novel genes that are under autocrine regulation by IL6 in human endothelial cells were identified. Overall, our data indicate that IL6 acts in an autocrine manner to regulate basal cellular functions, such as cell cycle regulation, signaling, and cellular movement, and suggests that the autocrine functions of IL6 in human endothelial cells are mediated via IL6 classic signaling.

Keyphrases

endothelial cells
cell cycle
high glucose
vascular endothelial growth factor
cell proliferation
gene expression
induced pluripotent stem cells
machine learning
pluripotent stem cells
dna methylation
oxidative stress
genome wide