Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis-Specific Antibody-Positive Inflammatory Myopathies.
Yusuke SugimoriYukiko IwasakiYusuke TakeshimaMai OkuboSatomi KobayashiHiroaki HatanoSaeko YamadaMasahiro NakanoRyochi YoshidaMineto OtaYumi TsuchidaYasuo NagafuchiKenichi ShimaneKen YoshidaDaitaro KurosakaShuji SumitomoHirofumi ShodaKazuhiko YamamotoTomohisa OkamuraKeishi FujioPublished in: ACR open rheumatology (2023)
Unique gene expression patterns in patients with IIM with different disease activity levels and MSA types suggest different pathophysiologies. Especially, B cells may contribute to common and MSA-specific immunological pathways in IIM.