Could FiLaC™ be effective in the treatment of anal fistulas? A systematic review of observational studies and proportional meta-analysis.

Maximos FrountzasK StergiosC NikolaouI BellosD SchizasD LinardoutsosK KontzoglouG VaosA B WilliamsK Toutouzas

Published in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2020)

FiLaC™ seems to be an efficient therapeutic option for perianal fistula disease with an adequate level of safety that preserves quality of life. Nevertheless, randomized trials need to be designed to compare FiLaC™ with other procedures for the management of anal fistulas such as ligation of intersphincteric fistula tract, anal advancement flaps, fibrin glue, collagen paste, autologous adipose tissue, fistula plug and video-assisted anal fistula treatment.

Keyphrases

adipose tissue
high grade
systematic review
randomized controlled trial
bone marrow
stem cells
mass spectrometry
high fat diet
insulin resistance
combination therapy
meta analyses
high resolution
mesenchymal stem cells
molecularly imprinted