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Elevated Id2 expression causes defective meiosis and spermatogenesis in mice.

Zhen HeRong-Ge YanQin-Bang ShangQi-En Yang
Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2023)
ID2 protein is expressed in spermatocytes, and its genetic ablation in the germline does not affect spermatogenesis, likely due to genetic compensation of its family members. However, forced Id2 expression changes meiosis progression and causes defects in spermiogenesis. These data provide important evidence that ID proteins play pivotal roles in male meiosis and spermatid development.
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