Association of High Cardiovascular Fitness and the Rate of Adaptation to Heat Stress.
Małgorzata Teresa ŻychowskaAlicja Nowak-ZaleskaGrzegorz ChruścińskiRyszard ZaleskiJan MieszkowskiBartłomiej NiespodzińskiRoman TymańskiAndrzej KochanowiczPublished in: BioMed research international (2018)
This study aimed to compare changes in genes expression associated with inflammation and apoptosis in response to heat stress caused by sauna between people with varying cardiorespiratory fitness levels. We hypothesis that high cardiorespiratory level caused higher positive changes after four weeks of sauna bathing. Blood samples were taken at rest before and after the first and last sauna sessions and 48 hours after the last sauna session and used to assay HSP70 (HSPA1A), HSP27 (HSPB1), interleukin 6 (IL6), and interleukin 10 (IL10) genes expression in blood with quantitative real-time qRT-PCR. Overall, small decreases in rest values of HSPA1A and IL6 mRNA, increase in HSPB1 mRNA, and a significant increase in IL10 mRNA were observed after four weeks of exposure to heat stress. Our findings suggest that an adaptive response to heat stress (an anti-inflammatory response) occurs faster in people with higher cardiorespiratory fitness.
Keyphrases
- heat stress
- heat shock
- heat shock protein
- inflammatory response
- binding protein
- poor prognosis
- oxidative stress
- genome wide
- high intensity
- endoplasmic reticulum stress
- gene expression
- cell death
- high throughput
- physical activity
- lipopolysaccharide induced
- cell cycle arrest
- bioinformatics analysis
- lps induced
- mass spectrometry
- single cell