SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter.

Zhenyang GuoXueting YuShuang ZhaoXin ZhongDong HuangRunyang FengPeng LiZheyan FangYiqing HuZhentao ZhangMukaddas AbdurahmanLei HuangYun ZhaoXiangdong WangJunbo GeHua Li

Published in: Clinical and translational medicine (2023)

Our results revealed an epigenetic mechanism associated with SIRT6 and Ero1α expression and highlighted the therapeutic potential of targeting the SIRT6-HIF1α/p300-Ero1α axis.

Keyphrases

oxidative stress
endothelial cells
ischemia reperfusion injury
dna methylation
gene expression
poor prognosis
dna damage
diabetic rats
induced apoptosis
single cell
cancer therapy
vascular endothelial growth factor
long non coding rna
binding protein
histone deacetylase