Association of CD47 Expression with Clinicopathologic Characteristics and Survival Outcomes in Muscle Invasive Bladder Cancer.

Zin W MyintZena ChahineRani JayswalSara Emily BachertRobert J McDonaldStephen E StrupAndrew C JamesPatrick J HensleyDerek B Allison

Published in: Journal of personalized medicine (2023)

CD47 expression was not a predictive nor prognostic marker for MIBC patients. However, expression of CD47 was detected in nearly half of MIBCs, and future studies are needed to explore the potential role of anti-CD47 therapy in these patients. Furthermore, there was a slight positive trend in decreased CD47 levels (from TURBT to RC) in patients receiving NAC. As a result, more research is needed to understand how NAC may modify immune surveillance mechanisms in MIBC.

Keyphrases

poor prognosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
transcription factor
nk cells
public health
stem cells
binding protein
bone marrow
climate change