Silencing SPP1 in M2 macrophages inhibits the progression of castration-resistant prostate cancer via the MMP9/TGFβ1 axis.

Saipeng ChenBingqian DengFuhan ZhaoHang YouYouxin LiuLanglang XieGuojing SongZhansong ZhouGang HuangWenhao Shen

Published in: Translational andrology and urology (2024)

We have found that the high expression of SPP1 in M2 macrophages promotes the progression of CRPC through cell-cell interactions. These findings can contribute to the development of novel therapeutic approaches for combating this deadly disease.

Keyphrases

single cell
cell therapy
poor prognosis
epithelial mesenchymal transition