Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment.
Pengfei LiYunjeong KimChamandi S DampallaHarry Nhat NguyenDavid K MeyerholzDavid K JohnsonScott LovellWilliam C GroutasStanley PerlmanKyeong-Ok ChangPublished in: mBio (2023)
efficacy of 3CLpro inhibitors for their broad-spectrum activity against both SARS-CoV-2 and MERS-CoV infections using the fatal animal models. The results suggest that these are promising candidates for further development as broad-spectrum direct-acting antivirals against highly virulent human coronaviruses.