High expression of microRNA-199a-5p is associated with superior clinical outcomes in patients with locally advanced rectal cancer.

Dong Won BaekGyeonghwa KimByung Woog KangHye Jin KimSu Yeon ParkJun Seok ParkGyu-Seog ChoiMin Kyu KangKeun HurJong Gwang Kim

Published in: Journal of cancer research and clinical oncology (2019)

High expression of tissue miR-199a/b-3p, miR-199a-5p, and miR-199b-5p was significantly associated with response to CRT, and a high level of tissue miR-199a-5p was associated with superior survival outcomes. Also, upregulated exosomal miR-199b-5p correlated with CRT response, reflecting its promise as a circulating biomarker of CRT response in patients with LARC.

Keyphrases

rectal cancer
locally advanced
poor prognosis
cardiac resynchronization therapy
long non coding rna
neoadjuvant chemotherapy
squamous cell carcinoma
cell proliferation
radiation therapy
heart failure
phase ii study
long noncoding rna
lymph node
study protocol