Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation.
Ekaterina EsaulovaClaudia CantoniIrina ShchukinaKonstantin ZaitsevRobert C BucelliGregory F WuMaxim N ArtyomovAnne H CrossBrian T EdelsonPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
High-resolution single-cell gene expression analysis clearly distinguishes distinct myeloid cell types present within the CSF of subjects with neuroinflammation. A population of microglia exists within the human CSF, which is detectable by surface protein expression. The function of these cells during immunity and disease requires further investigation.
Keyphrases
- single cell
- rna seq
- induced apoptosis
- gene expression
- endothelial cells
- high throughput
- high resolution
- cell cycle arrest
- inflammatory response
- induced pluripotent stem cells
- lipopolysaccharide induced
- traumatic brain injury
- acute myeloid leukemia
- bone marrow
- lps induced
- pluripotent stem cells
- neuropathic pain
- endoplasmic reticulum stress
- stem cells
- cerebrospinal fluid
- cognitive impairment
- oxidative stress
- spinal cord injury
- cell proliferation
- pi k akt
- immune response
- cerebral ischemia
- brain injury
- subarachnoid hemorrhage