Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
Lin FuJimin DuDavid FurkertMegan L ShiptonXiaoqi LiuTim AguirreAlfred C ChinAndrew M RileyBarry V L PotterDorothea FiedlerXu ZhangYi ZhuChenglai FuPublished in: Cardiovascular research (2024)
Our findings revealed that 5-InsP7 is a physiological regulator of adiponectin biosynthesis that is amenable to pharmacological intervention for cardioprotection.
Keyphrases
- metabolic syndrome
- insulin resistance
- randomized controlled trial
- acute myocardial infarction
- heart failure
- cerebral ischemia
- single cell
- transcription factor
- atrial fibrillation
- type diabetes
- adipose tissue
- blood brain barrier
- acute coronary syndrome
- percutaneous coronary intervention
- subarachnoid hemorrhage
- brain injury