Key enzyme in charge of ketone reabsorption of renal tubular SMCT1 may be a new target in diabetic kidney disease.

Zhenhong GuoFeifei ZhongMeng HouJinlan XieA Zhong ZhangXinran LiYuan LiBao Cheng ChangJuhong Yang

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)

Decreased SMCT1 expression and its ketone reabsorption function play an important role in the occurrence of DKD. SMCT1 may be a new promising target in treating DKD.

Keyphrases

poor prognosis
risk assessment
type diabetes
long non coding rna
endothelial cells
high glucose