LAMP3 induces ectopic TLR7 expression in salivary gland epithelial cells and amplifies type I IFN production in Sjögren's disease.

Hiroyuki Nakamura Tsutomu TanakaChangyu ZhengSandra A AfioneTatsuya AtsumiMasayuki NoguchiFabiola Reis OliveiraAna Carolina F MottaFernando ChahudEduardo Melani Rocha Blake M WarnerJohn A Chiorini

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Epithelial LAMP3 misexpression can be induced through enhanced type I IFN response in salivary glands. In addition, LAMP3 can promote type I IFN production via ectopic TLR7 expression in salivary gland epithelial cells. This positive feed-back loop can contribute to maintaining LAMP3 misexpression and amplifying type I IFN production in salivary glands, which plays an essential role in the pathophysiology of SjD.

Keyphrases

immune response
loop mediated isothermal amplification
dendritic cells
poor prognosis
toll like receptor
inflammatory response
sensitive detection
binding protein
long non coding rna
nuclear factor
transcription factor
disease activity
oxidative stress
diabetic rats