P16INK4a expression in patients with penile cancer.
Vicenilma de Andrade MartinsJaqueline Diniz PinhoAntonio Augusto Lima Teixeira JúniorLeudivan Ribeiro NogueiraFábio França SilvaVictor Eduardo MaulenAndré Salim KhayatJosé de Ribamar Rodrigues CalixtoHerikson Araújo CostaLeandra Naira Zambelli RamalhoVicenilma de Andrade MartinsPublished in: PloS one (2018)
Our study, using fresh tissue samples, showed the highest incidence of HPV compared to that observed in the literature. Expression of the p16INK4a protein was significantly associated with the presence of HR-HPV and this expression may serve as a marker for the presence of the virus. The p16INK4a protein was not associated with the histological prognostic parameters, with the exception of tumor subtype, nor with patient survival. In the results, we showed that the objective of the present study was reached.