Thrombopoietin and collagen in low doses cooperatively induce human platelet activation.

Tomoaki DoiTakamitsu HoriTakashi OnumaDaisuke MizutaniKyohei UedaYukiko EnomotoRie Matsushima-NishiwakiKumiko TanabeTomoyuki HiokiHaruhiko TokudaToru IwamaHiroki IidaOsamu KozawaShinji Ogura

Published in: Acute medicine & surgery (2022)

These results strongly suggest that TPO and collagen in low doses cooperatively potentiate human platelet activation through both Rac and Rho/Rho-kinase mediated pathways.

Keyphrases

endothelial cells
protein kinase
induced pluripotent stem cells
pluripotent stem cells
smooth muscle
tyrosine kinase
tissue engineering