Peripherally acting μ-opioid antagonist for the treatment of opioid-induced constipation: Systematic review and meta-analysis.

Kenichi NishieShuhei YamamotoTakayoshi YamagaNaoto HorigomeMasayuki Hanaoka

Published in: Journal of gastroenterology and hepatology (2019)

Peripherally acting μ-opioid receptor antagonist has been shown to be effective and durable for patients with OIC and is the only drug with confirmed evidence in meta-analysis. The possibility of publication bias was the limitation of this study.

Keyphrases

chronic pain
pain management
systematic review
drug induced
diabetic rats
meta analyses
randomized controlled trial
emergency department
oxidative stress
abdominal pain