Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [11 C]PBR28 and Machine Learning Analysis.
Aurelija JucaiteZsolt CselényiWilliam C KreislEugenii A RabinerAndrea VarroneRichard E CarsonJuha O RinneAlicia SavageMagnus SchouPeter JohnströmPer SvenningssonOlivier RascolWassillios G MeissnerPaolo BaroneKlaus SeppiHoracio KaufmannGregor K WenningWerner PoeweLars FardePublished in: Movement disorders : official journal of the Movement Disorder Society (2021)
We found a pattern of significantly increased regional glial TSPO binding in patients with MSA. Intriguingly, our data are in line with severe neuroinflammation in MSA. Glia imaging may have potential to support clinical MSA diagnosis and patient stratification in clinical trials on novel drug therapies for an α-synucleinopathy that remains strikingly incurable. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- positron emission tomography
- computed tomography
- machine learning
- clinical trial
- high resolution
- pet imaging
- big data
- artificial intelligence
- pet ct
- case report
- lipopolysaccharide induced
- systematic review
- emergency department
- cognitive impairment
- early onset
- randomized controlled trial
- dna binding
- neuropathic pain
- phase ii
- lps induced
- fluorescence imaging
- drug induced
- data analysis
- study protocol
- brain injury
- climate change
- double blind
- phase iii