Neonatal resuscitation with continuous chest compressions and high frequency percussive ventilation in preterm lambs.
Evan M GiustoDeepika SankaranAmy LesneskiHoussam JoudiMorgan HardieVictoria HammittLida ZeinaliSatyan LakshminrusimhaPayam ValiPublished in: Pediatric research (2023)
Ventilation is the most important intervention in newborn resuscitation. Currently recommended 3:1 compression-to-ventilation ratio is associated with hypercarbia and poor oxygen delivery to the brain. Providing uninterrupted continuous chest compressions during high frequency percussive ventilation is feasible in a lamb model of perinatal cardiac arrest, and demonstrates improved gas exchange and oxygen delivery to the brain. This is the first study in premature lambs evaluating high frequency percussive ventilation with asynchronous chest compressions and lays the groundwork for future clinical studies to optimize gas exchange and hemodynamics during chest compressions in newborns.
Keyphrases
- high frequency
- cardiopulmonary resuscitation
- cardiac arrest
- transcranial magnetic stimulation
- respiratory failure
- mechanical ventilation
- pregnant women
- white matter
- randomized controlled trial
- resting state
- low birth weight
- room temperature
- intensive care unit
- multiple sclerosis
- acute respiratory distress syndrome
- brain injury
- preterm birth
- atrial fibrillation
- carbon dioxide
- preterm infants
- cerebral ischemia
- blood brain barrier
- ionic liquid