CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis.
Janardhan Keshav KarapurkarMin-Seong KimJencia Carminha ColacoBharathi SureshNeha SarodayaDong-Ho KimChang-Hwan ParkSeok-Ho HongKye-Seong KimSeok-Ho HongPublished in: Journal of experimental & clinical cancer research : CR (2023)
The findings of this study indicate that USP3 is a critical factor that blocks neuronal differentiation, which can lead to neuroblastoma. We envision that targeting USP3 in neuroblastoma tumors might provide an effective therapeutic differentiation strategy for improved survival rates of neuroblastoma patients.
Keyphrases
- genome wide
- crispr cas
- end stage renal disease
- newly diagnosed
- dna methylation
- ejection fraction
- genome editing
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- small molecule
- gene expression
- drug delivery
- cerebral ischemia
- protein protein
- amino acid
- cancer therapy
- blood brain barrier
- subarachnoid hemorrhage