The impact of body mass index on breast cancer incidence among women at increased risk: an observational study from the International Breast Intervention Studies.
Samuel George SmithIvana SestakMichelle A MorrisMichelle HarvieAnthony HowellJohn ForbesJack CuzickPublished in: Breast cancer research and treatment (2021)
Higher BMI is associated with greater breast cancer risk in postmenopausal women at increased risk of the disease, but no effect was observed in premenopausal women. The lack of interaction between BMI and treatment group on breast cancer risk suggests women are likely to experience benefit from preventive therapy regardless of their BMI. Trial registration Both trials were registered [IBIS-I: ISRCTN91879928 on 24/02/2006, retrospectively registered ( http://www.isrctn.com/ISRCTN91879928 ); IBIS-II: ISRCTN31488319 on 07/01/2005, retrospectively registered ( http://www.isrctn.com/ISRCTN31488319 )].
Keyphrases
- breast cancer risk
- body mass index
- postmenopausal women
- weight gain
- bone mineral density
- randomized controlled trial
- clinical trial
- physical activity
- polycystic ovary syndrome
- study protocol
- risk factors
- stem cells
- metabolic syndrome
- type diabetes
- pregnant women
- body composition
- pregnancy outcomes
- mesenchymal stem cells
- replacement therapy
- cervical cancer screening