Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.

Amandine ViauMaroua BaazizAmandine AkaManal MazloumClément NguyenE Wolfgang KuehnFabiola TerziFrank Bienaimé

Published in: Journal of the American Society of Nephrology : JASN (2020)

STAT3 appears to repress the expression of proinflammatory cytokines and restrict immune cell infiltration in ADPKD. Our findings suggest that STAT3 is not a critical driver of cyst growth in ADPKD but rather plays a major role in the crosstalk between immune and tubular cells that shapes disease expression.

Keyphrases

polycystic kidney disease
poor prognosis
cell proliferation
induced apoptosis
oxidative stress
binding protein
cell cycle arrest
long non coding rna
high glucose
cell death
endoplasmic reticulum stress