Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells.

Chiara MarchioriMelania ScarpaAndromachi KotsaftiSusan MorganMatteo FassanVincenza GuzzardoAndrea PorzionatoImerio AngrimanCesare RuffoloStefania SutStefano Dall'AcquaRomeo BardiniRaffaele De CaroCarlo CastoroMarco ScarpaIgnazio Castagliuolo

Published in: Journal of experimental & clinical cancer research : CR (2019)

This study provide evidence for a major role of CD80 in orchestrating immune surveillance of colon preneoplastic lesions and might help to develop novel approaches that exploit anti-tumor immunity to prevent and control colon cancer.

Keyphrases

oxidative stress
public health
poor prognosis
nk cells
dna damage
induced apoptosis
long non coding rna
binding protein
ulcerative colitis