Heparanase expression and activity are increased in platelets during clinical sepsis.

Alicia S EustesRobert A CampbellElizabeth A MiddletonNeal D TolleyBhanu Kanth ManneEmilie MontenontJesse W RowleyKrystin KrauelAntoinette BlairLi GuoYasuhiro KosakaIsabel M Medeiros-de-MoraesMarcus LacerdaEugenio D HottzHugo Castro Faria NetoGuy A ZimmermanAndrew S WeyrichAaron PetreyMatthew T Rondina

Published in: Journal of thrombosis and haemostasis : JTH (2021)

During clinical sepsis HPSE, translation, and enzymatic activity are increased in platelets. Increased expression of the active form of HPSE protein is associated with sepsis-associated mortality.

Keyphrases

septic shock
acute kidney injury
poor prognosis
intensive care unit
binding protein
type diabetes
cardiovascular events
risk factors
long non coding rna
amino acid
red blood cell
nitric oxide