Effectiveness and Safety of XEN45 in Eyes with High Myopia and Open-angle Glaucoma.

Thirty-one eyes were included (96.8% with a primary-OAG diagnosis). The mean refraction was -13.2±5.6 (range: -6.75 to-23.0) Diopters. In the overall study sample, preoperative mean IOP (95% CI) was significantly lowered from 23.5 (20.5 to 26.4) mmHg to 13.0 (12.2 to 13.8) mmHg at the last follow-up visit, P<0.0001. At the last follow-up visit, 16 (57.1%) eyes achieved an IOP ≤14 mmHg, 11 (68.9%) of them without treatment. The number of ocular-hypotensive medications was significantly reduced from 3.0±1.1 drugs at preoperatively to 0.6±1.0 drugs at the last follow-up visit, P<0.0001. Median (95% CI) follow-up was 24.0 (12.0-24.0) months. Linear regression analysis showed a significant correlation between the preoperative refraction and the IOP lowering (r=0.43, P=0.0155). Needling procedure was performed in 11 eyes (39.3%) and hypotony (defined as an IOP <6 mm Hg) was observed in 8 eyes (28.6%) during the first post-operative day and remained for a week. Conclusion: While the Xen implant effectively lowered intraocular pressure in highly myopic eyes with glaucoma, the incidence of hypotony was high, and in most cases resolved within the first month with medical management and monitoring.