Drug characteristics derived from kinetic modeling: combined 11 C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A.

Mika NaganawaJean-Dominique GallezotSjoerd J FinnemaRalph Paul MaguireJoël MercierNabeel B NabulsiSophie KervynShannan HenryJean-Marie NicolasYiyun HuangMing-Kai ChenJonas HannestadHenrik KlitgaardArmel StockisRichard E Carson

Published in: EJNMMI research (2022)

Under appropriate conditions, this advanced nonlinear model can directly estimate entry rates of drugs into tissue by analysis of PET TACs. Using a conservative statistical cutoff, BRV enters the brain at least sevenfold faster than LEV.

Keyphrases

pet imaging
positron emission tomography
endothelial cells
induced pluripotent stem cells
resting state
white matter
pluripotent stem cells
emergency department
functional connectivity
cerebral ischemia
pet ct
multiple sclerosis
electronic health record