Mesenchymal stem cells derived from adipose accelerate the progression of colon cancer by inducing a MT-CAFs phenotype via TRPC3/NF-KB axis.

Chunling XueYang GaoXuechun LiMingjia ZhangYing YangQin HanZhao SunChunmei BaiRobert Chunhua Zhao

Published in: Stem cell research & therapy (2022)

These results indicate that TRPC3 expressed on MT-CAFs plays a critical role in tumor progression via the NF-KB signaling pathway, and is correlated with poor prognosis in colon cancer patients. Therefore, TRPC3 may be a novel therapeutic target for the treatment of colon cancer.

Keyphrases

poor prognosis
signaling pathway
pi k akt
long non coding rna
mesenchymal stem cells
vascular smooth muscle cells
lps induced
epithelial mesenchymal transition
induced apoptosis
oxidative stress
nuclear factor
umbilical cord
adipose tissue
bone marrow
type diabetes
metabolic syndrome
immune response
cell therapy