Heparin-LL37 complexes are less cytotoxic for human dental pulp cells and have undiminished antimicrobial and LPS-neutralizing abilities.
K YoshidaShigeki SuzukiM Kawada-MatsuoJ NakanishiS Hirata-TsuchiyaH KomatsuzawaS YamadaH ShibaPublished in: International endodontic journal (2019)
Heparin-LL37 complexes generated at suitable concentration ratios are easy to make, are less cytotoxic and are broad-range antimicrobial materials that can neutralize LPS by providing LL37 in accordance with the amount of free LPS. They may be a potential treatment to save dental pulp tissue from the acute inflammation exacerbated by invading bacteria and the LPS they release.
Keyphrases
- inflammatory response
- anti inflammatory
- induced apoptosis
- venous thromboembolism
- endothelial cells
- oxidative stress
- growth factor
- liver failure
- cell cycle arrest
- risk assessment
- respiratory failure
- signaling pathway
- hepatitis b virus
- cell proliferation
- intensive care unit
- pluripotent stem cells
- induced pluripotent stem cells
- human health
- endoplasmic reticulum stress
- aortic dissection
- replacement therapy
- smoking cessation