The efficacy and safety of venetoclax therapy in elderly patients with relapsed, refractory chronic lymphocytic leukaemia.
Toby Andrew EyreLindsey E RoekerChristopher P FoxSatyen H GohillRenata WalewskaHarriet S WalterFrancesco ForconiAngus BroomArvind ArumainathanDanielle M BranderJohn N AllanStephen J SchusterBrian T HillFrederick LansiganBruce D ChesonNicole LamannaCatherine C CoombsPaul M BarrAlan P SkarbnikMazyar ShadmanChaitra S UjjaniLaurie PearsonJohn M PagelRyan JacobsAnthony R MatoPublished in: British journal of haematology (2019)
Elderly chronic lymphocytic leukaemia (CLL) patients treated outside of trials have notably greater toxicity with the Bruton's tyrosine kinase inhibitor ibrutinib compared to younger patients. It is not known whether the same holds true for the B-cell lymphoma 2 inhibitor venetoclax. We provide a comprehensive analysis of key safety measures and efficacy in 342 patients comparing age categories ≥75 and <75 years treated in the relapsed, refractory non-trial setting. We demonstrate that venetoclax has equivalent efficacy and safety in relapsed/refractory CLL patients who are elderly, the majority of whom are previous ibrutinib-exposed and therefore may otherwise have few clear therapeutic options.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- chronic lymphocytic leukemia
- diffuse large b cell lymphoma
- acute myeloid leukemia
- acute lymphoblastic leukemia
- prognostic factors
- clinical trial
- randomized controlled trial
- multiple myeloma
- oxidative stress
- mesenchymal stem cells
- bone marrow
- open label