Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.
Laís Vales MennittiAsha A M CarpenterElena LocheLucas C PantaleãoDenise S Fernandez-TwinnJosca Mariëtte SchoonejansHeather L BlackmoreThomas J AshmoreLuciana Pellegrini PisaniJohn A TadrossIain HargreavesSusan E OzannePublished in: International journal of obesity (2005) (2021)
Our findings demonstrate that maternal diet-induced obesity has detrimental effects on offspring body composition as well as hepatic phenotype that may be indicative of accelerated-ageing phenotype. These whole-body and cellular phenotypes were associated with age-dependent changes in expression of miRNA-582 that might contribute mechanistically to the development of metabolic disorders in the older progeny.
Keyphrases
- middle aged
- body composition
- poor prognosis
- insulin resistance
- metabolic syndrome
- high fat diet
- weight loss
- weight gain
- birth weight
- type diabetes
- resistance training
- bone mineral density
- high fat diet induced
- binding protein
- pregnancy outcomes
- body mass index
- physical activity
- preterm birth
- gestational age
- community dwelling