A Screening of Native (Poly)phenols and Gut-Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan-3-ol Metabolite.

Josep RubertPamela GattoMichael PancherViktoryia SidarovichClaudio CurtiPedro Mena Daniele Del RioAlessandro QuattroneFulvio Mattivi

Published in: Molecular nutrition & food research (2022)

A chronic exposure to (4R)-5-(3',4'-dihydroxyphenyl)-γ-valerolactone may lead to a reduced CRC risk. Daily intake of monomeric, oligomeric, and polymeric flavan-3-ols may increase the colonic concentrations of this metabolite, and, in turn, this compound may act locally interacting with intestinal epithelial cells, precancerous and cancer cells.

Keyphrases

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