Tetrabromobisphenol A Promotes the Osteoclastogenesis of RAW264.7 Cells Induced by Receptor Activator of NF-kappa B Ligand In Vitro.

So Young Park Eun Mi Choi Kwang Sik Suh Hyun Sook Kim Sang Ouk Chin Sang Youl Rhee Deog Yoon Kim Seungjoon Oh Suk Chon

Published in: Journal of Korean medical science (2019)

This study suggests that TBBPA promotes osteoclast differentiation and activity. The mechanism of TBBPA-stimulated osteoclastogenesis might include increased expression of several genes involved in osteoclast differentiation and reactive oxygen species production.

Keyphrases

nuclear factor
bone loss
reactive oxygen species
lps induced
induced apoptosis
poor prognosis
signaling pathway
toll like receptor
cell cycle arrest
oxidative stress
binding protein
inflammatory response
pi k akt
cell death
endoplasmic reticulum stress