Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins.
Ting ZhouHuan YangCarmel AssaElise DeRooJack BontekoeBrian BurkelSuzanne M PonikHong S Lu (吕红)Alan DaughertyBo LiuPublished in: bioRxiv : the preprint server for biology (2024)
TSP1 expression by myeloid cells negatively regulates aneurysm rupture, likely through promoting the matrix repair phenotypes of vascular smooth muscle cells thereby increasing the strength of the vascular wall.
Keyphrases
- extracellular matrix
- vascular smooth muscle cells
- induced apoptosis
- dendritic cells
- angiotensin ii
- bone marrow
- acute myeloid leukemia
- poor prognosis
- cell cycle arrest
- coronary artery
- aortic valve
- pulmonary artery
- left ventricular
- cell death
- binding protein
- heart failure
- endoplasmic reticulum stress
- immune response
- long non coding rna
- aortic dissection
- pulmonary arterial hypertension