Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation.
Srikanth PerikeFrancisco J Gonzalez-GonzalezIssam H Abu-TahaFrederick W DamenKen S LizamaAnahita AboonabiAndrielle E CapoteYuriana Aguilar-SanchezBenjamin S LevinZhenbo HanArvind SridharJacob GrandJody L MartinJoseph G AkarChad M WarrenR John SolaroSang-Ging OngDawood DarbarCraig J GoergenBeata M WolskaDobromir DobrevXander H T WehrensMark D McCauleyPublished in: bioRxiv : the preprint server for biology (2023)
AF patients exhibit increased levels of PPP1R12C protein compared to controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- end stage renal disease
- heart failure
- percutaneous coronary intervention
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cell proliferation
- smooth muscle
- protein protein
- prognostic factors
- binding protein
- coronary artery disease
- amino acid
- patient reported outcomes
- small molecule
- cancer therapy
- acute coronary syndrome
- left ventricular