Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine.
Heba AbdelrazikEmanuele GiordanoGiovanni Barbanti BrodanoCristiana GriffoniElena De FalcoAlessandra PelagalliPublished in: International journal of molecular sciences (2019)
Mesenchymal stem cells (MSC) have piqued worldwide interest for their extensive potential to treat a large array of clinical indications, their unique and controversial immunogenic and immune modulatory properties allowing ample discussions and debates for their possible applications. Emerging data demonstrating that the interaction of biomaterials and physical cues with MSC can guide their differentiation into specific cell lineages also provide new interesting insights for further MSC manipulation in different clinical applications. Moreover, recent discoveries of some regulatory molecules and signaling pathways in MSC niche that may regulate cell fate to distinct lineage herald breakthroughs in regenerative medicine. Although the advancement and success in the MSC field had led to an enormous increase in the amount of ongoing clinical trials, we still lack defined clinical therapeutic protocols. This review will explore the exciting opportunities offered by human and animal MSC, describing relevant biological properties of these cells in the light of the novel emerging evidence mentioned above while addressing the limitations and challenges MSC are still facing.
Keyphrases
- mesenchymal stem cells
- clinical trial
- cell fate
- physical activity
- induced apoptosis
- signaling pathway
- endothelial cells
- cell therapy
- single cell
- umbilical cord
- bone marrow
- stem cells
- cell proliferation
- risk assessment
- machine learning
- cell death
- epithelial mesenchymal transition
- oxidative stress
- pluripotent stem cells
- artificial intelligence
- data analysis
- advance care planning