Dissecting the role of toll-like receptor 7 in pancreatic cancer.

Maren StarkMarina NicolaiMarina TaturaCorinna U KeberAndreas KaufmannHo-Ryun ChungEmily P SlaterChristopher HeeschenRita T LawlorAldo ScarpaDetlef K BartschThomas M GressStefan BauerMalte Buchholz

Published in: Cancer medicine (2023)

TLR7 may have opposing functions in tumor versus stroma cells. Further work is required to more precisely dissect the roles of TLR7 and its ligands in different populations of epithelial and stromal cells and to understand their relative contributions to tumor progression.

Keyphrases

toll like receptor
inflammatory response
nuclear factor
induced apoptosis
immune response
cell cycle arrest
poor prognosis
endoplasmic reticulum stress
signaling pathway
long non coding rna
genetic diversity