Characterization of nano-hydroxyapatite incorporated carboxymethyl chitosan composite on human dental pulp stem cells.

Ishwarya Gurucharan Balasubramanian Saravana Karthikeyan Mahalaxmi Sekar Kaviya Baskar Gurusamy Rajkumar Vijayakumar Dhivya Anil Kishen Seshadri Sankaranarayanan Natanasikamani Gurucharan

Published in: International endodontic journal (2023)

The results highlighted the odontogenic differentiation and biomineralization abilities of CSHA on hDPSCs with significant VEGF and DSPP gene upregulations. Further, CSHA exhibited enhanced mineralization activity than Biodentine, as evidenced by increased ALP, ARS and OPN activity on day 14. The nHAp-CMC scaffold has the potential to act as an effective pulp capping agent; however, this needs to be further validated through in-vivo animal studies.

Keyphrases

stem cells
endothelial cells
drug delivery
tissue engineering
genome wide
copy number
gene expression
risk assessment
dna methylation
cell therapy
bone marrow
hyaluronic acid
climate change
lactic acid
genome wide analysis