The Role of Hypoxia-Associated Long Non-Coding RNAs in Breast Cancer.
Vilma MaldonadoJorge Melendez-ZajglaPublished in: Cells (2022)
Breast cancer is the leading cause of cancer-related deaths in women worldwide. In the United States, even with earlier diagnosis and treatment improvements, the decline in mortality has stagnated in recent years. More research is needed to provide better diagnostic, prognostic, and therapeutic tools for these patients. Long non-coding RNAs are newly described molecules that have extensive roles in breast cancer. Emerging reports have shown that there is a strong link between these RNAs and the hypoxic response of breast cancer cells, which may be an important factor for enhanced tumoral progression. In this review, we summarize the role of hypoxia-associated lncRNAs in the classic cancer hallmarks, describing their effects on the upstream and downstream hypoxia signaling pathway and the use of them as diagnostic and prognostic tools.
Keyphrases
- long non coding rna
- poor prognosis
- signaling pathway
- end stage renal disease
- endothelial cells
- breast cancer cells
- ejection fraction
- chronic kidney disease
- breast cancer risk
- newly diagnosed
- papillary thyroid
- emergency department
- cardiovascular events
- cardiovascular disease
- metabolic syndrome
- risk factors
- patient reported outcomes
- squamous cell
- squamous cell carcinoma
- oxidative stress
- coronary artery disease
- lymph node metastasis
- cell proliferation
- adipose tissue
- pregnant women
- patient reported