Lack of repeatability of radiomic features derived from PET scans: Results from a 18 F-DCFPyL test-retest cohort.
Rudolf A WernerBilêl HabachaSusanne LütjeLena BundschuhAlekandser KosmalaMarkus EsslerThorsten DerlinTakahiro HiguchiConstantin LapaAndreas K BuckKenneth J PientaMartin A LodgeMario A EisenbergerMark C MarkowskiMartin G PomperMichael A GorinEric C FreySteven P RoweRalph A BundschuhPublished in: The Prostate (2023)
Many common radiomic features derived from a test-retest PET study had poor repeatability. Only Entropy and homogeneity achieved good repeatability, supporting the notion that those image biomarkers may be incorporated in future clinical trials. Those radiomic features based on high frequency aspects of images appear to lack the repeatability on PET to justify further study.